Chosen Solution
In order to avoid the sound from the optical drive on startup, I decided to just unplug the optical drive internally. However, I just left the wire fully unplugged but still hovering over its port. Could this cause any problems? I don’t think the back of the case is applying any pressure on connector but I’m not really sure. Maybe there is a better way to solve this problem?
The reason I asked what you had is my system isn’t doing running the optical drive that often. My OS test system is a 13” 2012 MacBook Pro. Let’s make sure your settings are set correctly. go into your preferences > Startup Disk and see if resetting it helps (with the optical drive plugged in), Next lets also reset the SMC and NVRAM How to reset the SMC of your MacReset NVRAM or PRAM on your Mac Let’s see where that leads us.
If you don’t want to use your optical drive you can remove it using this guide. If you just want to leave it unplugged I would recommend putting some anti-static tape around the head of the optical drive cable and then using the anti-static tape to tape it down so it doesn’t move around internally.